31 Citations
- M. RamírezM. Tolmasky
- 2017
Medicine, Chemistry
Molecules
Small molecules as well as complexes ionophore-Zn+2 or Cu+2 were found to inhibit the acetylation reaction and induced phenotypic conversion to susceptibility in bacteria harboring the aac(6′)-Ib gene.
- 162 [PDF]
- N. N. RudakovaM. AlekseevaV. Danilenko
- 2020
Biology, Environmental Science
Biology Bulletin Reviews
The inhibition of proteins that provide a natural level of bacterial resistance to a number of aminoglycoside antibiotics may help overcome multidrug resistance in pathogenic actinobacteria and expand the range of drugs used due to the synergistic effect of the antibiotic with the ARH inhibitor compound.
- M. MustafaR. Abdullah
- 2020
Medicine
The study findings suggest that the presence of missense and frameshift mutations may contribute to the elevated resistance to amikacin and gentamicin.
- 1
- Highly Influenced[PDF]
- A. ReisB. KolvenbachO. NunesP. Corvini
- 2019
Environmental Science, Medicine
New biotechnology
- 99
- M. HabiburrahmanV. SoetiknoWani Riselia SiraitM. Savira
- 2020
Medicine
Gonorrhea is one of the most often sexually transmitted infection in the world. In 2016, WHO stated the Southeast Asia region as the fourth-highest incidence rate and prevalence of gonorrhea. One of…
- 1
- A. YacoubaA. Olowo-OkereIsmaeel Yunusa
- 2021
Medicine
Annals of clinical microbiology and…
The heavy use of antibiotics during the CO VID-19 pandemic would likely worsen antibiotic resistance crisis and antibiotic stewardship should be strengthened in order to prevent the impacts of COVID-19 on the antibiotics resistance crisis.
- 39
- PDF
- Hervé NicoloffD. Andersson
- 2016
Medicine, Biology
The Journal of antimicrobial chemotherapy
IR was not limited to β-lactamase-producing bacteria, but was also caused by resistant bacteria carrying cytoplasmic antibiotic-modifying or -degrading enzymes that catalyse energy-consuming reactions requiring complex cellular cofactors.
- 74
- PDF
- Eon-Bee LeeKyubae Lee
- 2023
Medicine, Mathematics
Pharmaceuticals
This research focuses on combating the increasing problem of antimicrobial resistance, especially in Escherichia coli, by assessing the efficacy of aminoglycosides, and employs a pharmacodynamics (PD) model to analyze how different antibiotic concentrations affect bacterial growth.
- M. El-MongySh MohamedM. MabroukA. MohammedH. Hamza
- 2017
Medicine, Environmental Science
Journal of Biochemistry, Microbiology and…
There are significant improvements in the antimicrobial activity of tetracycline against E. coli isolated from milk due to the fennel oil contained medium and the sensitivity of Enterobacter spp.
- 1
- PDF
- A. El-BazG. Yahya Amira M. El-Ganiny
- 2021
Medicine
Antibiotics
This study revealed the high existence of MRSA and revealed the AacA4 gene and class I integron harboring aadA gene were predominant in MRSA isolates.
- 18 [PDF]
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162 References
- L. KotraJ. HaddadS. Mobashery
- 2000
Medicine, Chemistry
Antimicrobial Agents and Chemotherapy
The vast majority of aminoglycosides are bactericidal, they have predictable pharmacokinetics, and they often act in synergy with other antibiotics, properties that make them valuable as anti-infectives.
- 482
- PDF
- L. S. GonzálezJ. Spencer
- 1998
Medicine
American family physician
Single daily dosing of aminoglycosides appears to be safe, efficacious and cost effective, in certain clinical situations, such as patients with endocarditis or pediatric patients, traditional multiple dosing is still usually recommended.
- 223
- A. RobicsekJ. Strahilevitz D. Hooper
- 2006
Biology, Chemistry
Nature Medicine
Reduced susceptibility to ciprofloxacin in clinical bacterial isolates conferred by a variant of the gene encoding aminoglycoside acetyltransferase AAC(6′)-Ib, first reported in 2003 and now widely disseminated is described.
- 959
- H. GoldR. Moellering
- 1996
Medicine
The New England journal of medicine
Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender…
- 1,175
- M. RamírezM. Tolmasky
- 2010
Medicine, Chemistry
Drug resistance updates : reviews and…
- 739
- PDF
- M. Mingeot-LeclercqY. GlupczynskiP. Tulkens
- 1999
Medicine, Chemistry
Antimicrobial Agents and Chemotherapy
Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections and have a history marked by the successive introduction of a series of milestone compounds.
- 1,003
- PDF
- Clyde A. SmithE. Baker
- 2002
Chemistry, Medicine
Current drug targets. Infectious disorders
This review focuses on the structural details of the enzymes whose crystal structures are known and on the implications of these findings for devising novel strategies to overcome resistance to this broad class of antibiotics.
- 115
- B. D. Davis
- 1987
Chemistry, Medicine
Microbiological reviews
This review will examine the discovery of various aspects of aminoglycoside action and the resulting hypotheses and their problems, and discuss possible reasons for the delay in recognizing that membrane damage is central and is related to misreading.
- 420
- PDF
- J. Blanchard
- 1996
Chemistry, Medicine
Annual review of biochemistry
In spite of forty years of effective chemotherapy for tuberculosis, the molecular mechanisms of antibacterial compounds in Mycobacterium tuberculosis have only recently been revealed and present tuberculosis chemotherapies are threatened.
- 145
- PDF
- Sébastien CoyneP. CourvalinB. Périchon
- 2010
Medicine
Antimicrobial Agents and Chemotherapy
Overexpression of AdeABC, secondary to mutations in the adeRS genes encoding a two-component regulatory system, constitutes a major mechanism of multiresistance in A. baumannii.
- 439
- PDF
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