Aminoglycosides: Mechanisms of Action and Resistance | Semantic Scholar (2024)

31 Citations

Amikacin: Uses, Resistance, and Prospects for Inhibition
    M. RamírezM. Tolmasky

    Medicine, Chemistry

    Molecules

  • 2017

Small molecules as well as complexes ionophore-Zn+2 or Cu+2 were found to inhibit the acetylation reaction and induced phenotypic conversion to susceptibility in bacteria harboring the aac(6′)-Ib gene.

Genes of Aminoglycoside Phosphotransferases in Soil Bacteria of the Streptomyces Genus
    N. N. RudakovaM. AlekseevaV. Danilenko

    Biology, Environmental Science

    Biology Bulletin Reviews

  • 2020

The inhibition of proteins that provide a natural level of bacterial resistance to a number of aminoglycoside antibiotics may help overcome multidrug resistance in pathogenic actinobacteria and expand the range of drugs used due to the synergistic effect of the antibiotic with the ARH inhibitor compound.

Investigation for some Aminoglycosides Modifying Enzymes- Encoding Genes and Co-Resistance to Fluoroquinolones among Klebsiella pneumoniae Isolates from Different Clinical Cases
    M. MustafaR. Abdullah

    Medicine

  • 2020

The study findings suggest that the presence of missense and frameshift mutations may contribute to the elevated resistance to amikacin and gentamicin.

Biodegradation of antibiotics: the new resistance determinants - part I.
    A. ReisB. KolvenbachO. NunesP. Corvini

    Environmental Science, Medicine

    New biotechnology

  • 2019
  • 99
Solithromycin as A Potential Novel Antibiotic Against Neisseria Gonorrhoeae Resistance
    M. HabiburrahmanV. SoetiknoWani Riselia SiraitM. Savira

    Medicine

  • 2020

Gonorrhea is one of the most often sexually transmitted infection in the world. In 2016, WHO stated the Southeast Asia region as the fourth-highest incidence rate and prevalence of gonorrhea. One of

  • 1
Repurposing of antibiotics for clinical management of COVID-19: a narrative review
    A. YacoubaA. Olowo-OkereIsmaeel Yunusa

    Medicine

    Annals of clinical microbiology and…

  • 2021

The heavy use of antibiotics during the CO VID-19 pandemic would likely worsen antibiotic resistance crisis and antibiotic stewardship should be strengthened in order to prevent the impacts of COVID-19 on the antibiotics resistance crisis.

  • 39
  • PDF
Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes.
    Hervé NicoloffD. Andersson

    Medicine, Biology

    The Journal of antimicrobial chemotherapy

  • 2016

IR was not limited to β-lactamase-producing bacteria, but was also caused by resistant bacteria carrying cytoplasmic antibiotic-modifying or -degrading enzymes that catalyse energy-consuming reactions requiring complex cellular cofactors.

  • 74
  • PDF
A Pharmacodynamic Study of Aminoglycosides against Pathogenic E. coli through Monte Carlo Simulation
    Eon-Bee LeeKyubae Lee

    Medicine, Mathematics

    Pharmaceuticals

  • 2023

This research focuses on combating the increasing problem of antimicrobial resistance, especially in Escherichia coli, by assessing the efficacy of aminoglycosides, and employs a pharmacodynamics (PD) model to analyze how different antibiotic concentrations affect bacterial growth.

Role of Foeniculum vulgare oil on the antimicrobial activity of some antibiotics against resistant pathogenic Gram-negative bacteria
    M. El-MongySh MohamedM. MabroukA. MohammedH. Hamza

    Medicine, Environmental Science

    Journal of Biochemistry, Microbiology and…

  • 2017

There are significant improvements in the antimicrobial activity of tetracycline against E. coli isolated from milk due to the fennel oil contained medium and the sensitivity of Enterobacter spp.

  • 1
  • PDF
The Link between Occurrence of Class I Integron and Acquired Aminoglycoside Resistance in Clinical MRSA Isolates
    A. El-BazG. Yahya Amira M. El-Ganiny

    Medicine

    Antibiotics

  • 2021

This study revealed the high existence of MRSA and revealed the AacA4 gene and class I integron harboring aadA gene were predominant in MRSA isolates.

...

...

162 References

Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance
    L. KotraJ. HaddadS. Mobashery

    Medicine, Chemistry

    Antimicrobial Agents and Chemotherapy

  • 2000

The vast majority of aminoglycosides are bactericidal, they have predictable pharmacokinetics, and they often act in synergy with other antibiotics, properties that make them valuable as anti-infectives.

  • 482
  • PDF
Aminoglycosides: a practical review.
    L. S. GonzálezJ. Spencer

    Medicine

    American family physician

  • 1998

Single daily dosing of aminoglycosides appears to be safe, efficacious and cost effective, in certain clinical situations, such as patients with endocarditis or pediatric patients, traditional multiple dosing is still usually recommended.

  • 223
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
    A. RobicsekJ. Strahilevitz D. Hooper

    Biology, Chemistry

    Nature Medicine

  • 2006

Reduced susceptibility to ciprofloxacin in clinical bacterial isolates conferred by a variant of the gene encoding aminoglycoside acetyltransferase AAC(6′)-Ib, first reported in 2003 and now widely disseminated is described.

  • 959
Antimicrobial-drug resistance.
    H. GoldR. Moellering

    Medicine

    The New England journal of medicine

  • 1996

Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender

  • 1,175
Aminoglycoside modifying enzymes.
    M. RamírezM. Tolmasky

    Medicine, Chemistry

    Drug resistance updates : reviews and…

  • 2010
  • 739
  • PDF
Aminoglycosides: Activity and Resistance
    M. Mingeot-LeclercqY. GlupczynskiP. Tulkens

    Medicine, Chemistry

    Antimicrobial Agents and Chemotherapy

  • 1999

Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections and have a history marked by the successive introduction of a series of milestone compounds.

  • 1,003
  • PDF
Aminoglycoside antibiotic resistance by enzymatic deactivation.
    Clyde A. SmithE. Baker

    Chemistry, Medicine

    Current drug targets. Infectious disorders

  • 2002

This review focuses on the structural details of the enzymes whose crystal structures are known and on the implications of these findings for devising novel strategies to overcome resistance to this broad class of antibiotics.

  • 115
Mechanism of bactericidal action of aminoglycosides
    B. D. Davis

    Chemistry, Medicine

    Microbiological reviews

  • 1987

This review will examine the discovery of various aspects of aminoglycoside action and the resulting hypotheses and their problems, and discuss possible reasons for the delay in recognizing that membrane damage is central and is related to misreading.

  • 420
  • PDF
Molecular mechanisms of drug resistance in Mycobacterium tuberculosis.
    J. Blanchard

    Chemistry, Medicine

    Annual review of biochemistry

  • 1996

In spite of forty years of effective chemotherapy for tuberculosis, the molecular mechanisms of antibacterial compounds in Mycobacterium tuberculosis have only recently been revealed and present tuberculosis chemotherapies are threatened.

  • 145
  • PDF
Efflux-Mediated Antibiotic Resistance in Acinetobacter spp
    Sébastien CoyneP. CourvalinB. Périchon

    Medicine

    Antimicrobial Agents and Chemotherapy

  • 2010

Overexpression of AdeABC, secondary to mutations in the adeRS genes encoding a two-component regulatory system, constitutes a major mechanism of multiresistance in A. baumannii.

  • 439
  • PDF

...

...

Related Papers

Showing 1 through 3 of 0 Related Papers

    Aminoglycosides: Mechanisms of Action and Resistance | Semantic Scholar (2024)
    Top Articles
    Latest Posts
    Recommended Articles
    Article information

    Author: The Hon. Margery Christiansen

    Last Updated:

    Views: 6265

    Rating: 5 / 5 (70 voted)

    Reviews: 85% of readers found this page helpful

    Author information

    Name: The Hon. Margery Christiansen

    Birthday: 2000-07-07

    Address: 5050 Breitenberg Knoll, New Robert, MI 45409

    Phone: +2556892639372

    Job: Investor Mining Engineer

    Hobby: Sketching, Cosplaying, Glassblowing, Genealogy, Crocheting, Archery, Skateboarding

    Introduction: My name is The Hon. Margery Christiansen, I am a bright, adorable, precious, inexpensive, gorgeous, comfortable, happy person who loves writing and wants to share my knowledge and understanding with you.